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Image Search Results
Journal: Journal of Neuroinflammation
Article Title: Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS
doi: 10.1186/s12974-015-0429-y
Figure Lengend Snippet: Clinical disease course of active MOG 35-55 induced EAE in C57Bl/6 wildtype ( apoE +/+ ) and apoE -deficient ( apoE −/− ) mice. a In male (m) mice, the absence of apoE leads to an attenuated disease severity. b In contrast, in females (f), apoE deficiency results in a worse disease course. Data were pooled from two independent experiments. Clinical disease course was assessed using a 10-grade scale and depicted as mean ± SEM. Statistical analyses: median scores analyzed with Mann-Whitney U test from onset of disease (d8) until the end of observation (d35) (*** p < 0.001, ** p < 0.01) and for individual time points (# p < 0.05)
Article Snippet:
Techniques: MANN-WHITNEY
Journal: Journal of Neuroinflammation
Article Title: Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS
doi: 10.1186/s12974-015-0429-y
Figure Lengend Snippet: Neurofilament heavy chain (NfH) concentration in blood plasma of C57Bl/6 wildtype mice ( apoE +/+ ) and apoE -deficient ( apoE −/− ) mice after a MOG 35-55 -induced EAE indicates the extent of axonal damage. In the chronic phase (d26), male apoE +/+ mice show a significantly increased NfH concentration compared to male apoE −/− mice. NfH concentration was calculated as difference (Δ) between d26 and baseline (i.e., before EAE-induction). Statistical analyses: * p < 0.05 by Mann-Whitney U test
Article Snippet:
Techniques: Concentration Assay, Clinical Proteomics, MANN-WHITNEY
Journal: Journal of Neuroinflammation
Article Title: Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS
doi: 10.1186/s12974-015-0429-y
Figure Lengend Snippet: Relative apoE expression in the spinal cord at different time points of a MOG 35-55 -induced EAE in C57Bl/6 wildtype mice. Quantitative real-time PCR analyses show an increased apoE expression in the chronic phase (d35) of EAE in both females and males compared to untreated animals (BL). Statistical analyses: *** p < 0.001; one-way ANOVA (post test: Bonferroni’s multiple comparison test)
Article Snippet:
Techniques: Expressing, Real-time Polymerase Chain Reaction, Comparison